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Desitin Daily Defense Baby Diaper Rash Cream with Zinc Oxide - 4oz
$6.29
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About this item
Highlights
- Desitin Daily Defense Diaper Rash Cream to soothe, treat & prevent baby diaper rash
- The fast-acting formula of this infant diaper rash cream prevents diaper rash from the first use
- #1 choice for diaper rash relief by Pediatricians & parents, it is both easy to apply and remove
- It instantly forms a protective layer on your baby's skin for diaper rash relief and prevention
- Made with 13% zinc oxide, it is hypoallergenic and specially formulated for babies' tender skin
Description
Use Desitin Daily Defense Diaper Rash Cream every day to soothe, treat and prevent baby diaper rash. This hypoallergenic and pediatrician-tested formula instantly forms a protective barrier on your baby's tender skin and is clinically shown to provide diaper rash relief. The daily diaper rash cream is designed to work at the first hint of diaper rash to help heal and soothe your baby's skin. Made with fast-acting formula containing 13% zinc oxide skin protectant, this barrier cream helps seal out wetness and provides protection from the first use. It is dermatologist-tested and free of parabens, phthalates, fragrances and dyes, so it's gentle enough to use at every diaper change. The #1 choice of pediatricians and parents, the creamy formula goes on smoothly and wipes off easily, making Desitin Daily Defense Diaper Rash Cream your trusted partner for treating diaper rash from the first signs.
Scent: Unscented
Suggested Age: Newborn and Up
Health Facts: Dye-Free, Contains Zinc Oxide, Paraben-Free, Phthalate-Free, Hypoallergenic, No Fragrance Added, Aluminum-Free
Active Ingredient Strength Value: 13
Product Form: Cream
Primary Active Ingredient: Zinc Oxide
Package Quantity: 1
Net weight: 4 Ounces
Features: Pediatrician Tested, Soothing, Dermatologist Tested
TCIN: 13682489
UPC: 074300003016
Item Number (DPCI): 007-08-0484
Origin: Made in the USA or Imported
Healthcare Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers.
If the item details aren’t accurate or complete, we want to know about it.
Active ingredients
zinc oxide' '13.0%
Purpose
Skin protectantUses
• helps treat and prevent diaper rash • protects chafed skin due to diaper rash and helps seal out wetnessDirections
Directions • change wet and soiled diapers promptly • cleanse the diaper area • allow to dry • apply cream liberally as often as necessary, with each diaper change, especially at bedtime or anytime when exposure to wet diapers may be prolongedOther information
Sustainable Forestry Initiative (SFI) - Certified Chain of Custody At Least 10% Certified Forest Content - www.sfiprogram.org - SFI-00311, May stain clothing, © J&JCI 2018Inactive ingredients
inactive ingredients: water, mineral oil, petrolatum, beeswax, dimethicone, sorbitan sesquioleate, microcrystalline wax, peg-30 dipolyhydroxystearate, aloe barbadensis leaf extract, glycerin, tropolone, tocopheryl acetate, 1,2-hexanediol, caprylyl glycol, magnesium sulfate, potassium hydroxide, phenoxyethanol
Ingredients:
inactive ingredients: water, mineral oil, petrolatum, beeswax, dimethicone, sorbitan sesquioleate, microcrystalline wax, peg-30 dipolyhydroxystearate, aloe barbadensis leaf extract, glycerin, tropolone, tocopheryl acetate, 1,2-hexanediol, caprylyl glycol, magnesium sulfate, potassium hydroxide, phenoxyethanol
Shipping details
Estimated ship dimensions: 6.2 inches length x 2.4 inches width x 1.8 inches height
Estimated ship weight: 0.25 pounds
Return details
This item can be returned to any Target store or Target.com.
This item must be returned within 90 days of the date it was purchased in store, shipped, delivered by a Shipt shopper, or made ready for pickup.
See the return policy for complete information.
Q: Can it be used on toddlers as well?
submitted by Samantha - 1 year ago
A: Hi Samantha. This product can also be used by toddlers if you want to more about this you may go to our website https://www.desitin.com/diaper-rash-products/daily-defense-zinc-oxide-cream.
submitted byJohnson & Johnson - 1 year agoBrand expert
Q: Is it in a tube or in a jar?
submitted by CheapGuy - 1 year ago
A: Hello. Desitin Daily Defense Baby Diaper Rash Cream with Zinc Oxide - 4oz is in a tube packaging. Thank you.
submitted byJohnson & Johnson - 1 year agoBrand expert
Q: Is it odorless? I need it for an adult with a terrible tash but I've always hated the scent
submitted by Denise1954 - 1 year ago
A: No Fragrance Added.
submitted byJohnson & Johnson - 1 year agoBrand expert
Q: does this stain Destin Diaper rash cream
submitted by YogaKat - 2 years ago
A: Great question! This product is not made with dyes. Zinc Oxide, although not a dye, imparts a white color to the formula, and when used on the skin.
submitted byJohnson & Johnson - 2 years agoBrand expert
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Guests are saying
Desitin Daily Defense Cream is a highly effective solution for preventing and treating diaper rash in babies. Many guests appreciate its gentle formula, which contains safe ingredients like zinc oxide, making it suitable for sensitive skin. The cream spreads easily, absorbs well, and does not leave a greasy residue. Guests love its mild scent and convenient packaging, making it a must-have for daily use. Overall, it provides reliable protection and soothing relief for delicate skin.
Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
4.7 out of 5 stars with 4830 reviews
quality: 4.48 out of 5
value: 4.53 out of 5
87% would recommend
85 recommendations
5 out of 5 stars
8 January, 2026
originally posted on desitin.com
Greatfull
It's so good For baby I use everyday I need it everyday
4 out of 5 stars
4 January, 2026
originally posted on desitin.com
Requesting 4.8oz to be back in-stock
Desitin all 3 products are great and help with my baby to prevent diaper rash. Realized y'all bring back 16oz tub which is great for home use, but it will be great y'all bring back 4.8oz. Appreciated!!
5 out of 5 stars
2 January, 2026
originally posted on influenster.com
Super
This cream is the best, the results are great in a very short time, it acts, the consistency is good, it is creamy and the packaging is very good, it is not big, which is great for your bag
5 out of 5 stars
30 December, 2025
originally posted on influenster.com
Excellent product.
I love this cream; it's the best I've used since my baby was born, and since the first time I tried it, I haven't used anything else. It's not sticky or too greasy, and it perfectly protects my baby's skin. Since I started using it, she has never had diaper rash.
5 out of 5 stars
28 December, 2025
originally posted on influenster.com
Recommended
This cream is a product that I use daily with my baby, it helps him not to have pinkish or burns, since day 1 and thank God he has never suffered from burns, it has an excellent consistency, a super mild smell and he has not had allergies.
5 out of 5 stars
Thumbs up graphic, would recommend
28 December, 2025Verified purchase
Tried and true diaper rash cream
We’ve used this cream for all 3 of our kids and it’s worked great for us. It’s a true cream and not oily or liquidy as some of the alternatives are.
5 out of 5 stars
15 December, 2025
originally posted on influenster.com
A must-have in our diaper bag
I’ve been using Desitin Daily Defense for my twins and it really works. It helped clear up diaper rash quickly and also prevents new irritation when used daily. The texture is smooth and easy to apply, not overly thick, and it doesn’t have a strong smell.
5 out of 5 stars
Thumbs up graphic, would recommend
14 December, 2025Verified purchase
Diaper bag/changing atation essential
Helped so much with my son’s diaper rash! Thick so you don’t have to use much. This bottle will last forever!
5 out of 5 stars
10 December, 2025
originally posted on influenster.com
Great quality
Really like the ease of use, texture and value of this balm for starters. It is easy to apply, smells great, smooths and condition. It is non sticky has a good hold. It’s always comes in handy
5 out of 5 stars
25 November, 2025
originally posted on influenster.com
Good!
I’ve been using Desitin cream for my baby, and I’m really impressed. It works quickly to soothe any skin irritation and creates a long-lasting protective barrier — the durability of the effect is amazing. I also appreciate the ingredients, which are gentle and safe for sensitive skin. Highly recommend for everyday use! It easily helps to eliminate redness, has a pleasant texture, is easy to apply to the skin. Convenient and roomy packaging lasts a long time. I take it with me everywhere.
5 out of 5 stars
24 November, 2025
originally posted on influenster.com
Fast Relief & Gentle on Baby's Skin
This cream has become a must-have in our routine. The texture is smooth and easy to apply, and the consistency spreads evenly without being too thick. I love the compact 2 oz packaging because it’s perfect for the diaper bag and stores well without leaking or drying out. For maintenance, it stays in great condition even with daily use. My baby doesn’t get diaper rash often, but whenever she does and I put this on right away, the relief is almost instant. It’s gentle, effective, and very reliable.
5 out of 5 stars
Thumbs up graphic, would recommend
20 November, 2025Verified purchase
Eases redness
Desitin works perfectly for when my baby has any raw spots from wiping or her diaper. Having a breastfed baby with breastfed poops can cause quick irritation. This always helps ease any redness. It is gentle, effective, and easy to apply. A little bit goes a long ways!
5 out of 5 stars
17 November, 2025
originally posted on influenster.com
Our daily diaper cream - keeps rash away and a lit
We use this DAILY as the name of the product reads! It is our go to diaper cream for our twins and we must have gone through 50 tubs by now. The tub last a very long time as you don’t need a ton - it spreads so easily and really keeps rashes away! Easy to wipe off or wash off in the tub. My parents used Desitin with me and now I’m using it for my babies! It’s a classic for a reason.
5 out of 5 stars
17 November, 2025
originally posted on influenster.com
The best
Fragrance is ok. Coverage is perfect. Residue is ok. Skin/Bottom feels better after a few days. Packaging is nice. Its worth the price is think.
5 out of 5 stars
Thumbs up graphic, would recommend
6 November, 2025Verified purchase
Amazing product!!!
My baby had a horrible rash. I used the Desitin maximum strength and worked almost immediately. Now I’m using the Desitin daily defense on my baby. He hasn’t had any rash ever since I’m using this paste after every diaper change.
5 out of 5 stars
28 October, 2025
originally posted on influenster.com
I love it because it protects my baby
Desitin Daily Defense is your daily ally to protect your baby's delicate skin and treat diaper rash from the first signs. With a fast-acting and proven formula, this cream instantly creates a protective barrier to relieve discomfort and seal moisture. Recommended by pediatricians and parents, it is ideal to use with each diaper change as a preventive and relief measure.
5 out of 5 stars
Thumbs up graphic, would recommend
26 October, 2025
Daily Cream
We use this daily. Love the price point for the amount of product. A little goes a long way and creates a protective barrier.
5 out of 5 stars
24 October, 2025
originally posted on influenster.com
For the daily use of the baby
The desitin daily defense cream has a very good effectiveness, protects babies from diaper rash with soft and hypoallergenic ingredients its packaging is suitable to wear and has a simple smell, it has a price affordable to your pockets
5 out of 5 stars
24 October, 2025
originally posted on influenster.com
Good use daily for baby skin
Really helpful. I’m preventing rashes on my baby, good packaging for on the go and good pricing all around has no sent and is baby safe. Very effective.
2 out of 5 stars
23 October, 2025
originally posted on influenster.com
Not a fan
I didn’t care for Desitin. It never healed the diaper rash on my daughter. It also seemed to burn when I applied it because she would scream and scream.