New ArrivalsHealth & WellnessValentine’s DayClothing, Shoes & AccessoriesHomeKitchen & DiningGroceryHousehold EssentialsFurnitureOutdoor Living & GardenBabyToysVideo GamesElectronicsMovies, Music & BooksBeautyPersonal CareGift IdeasParty SuppliesCharacter ShopSports & OutdoorsBackpacks & LuggageSchool & Office SuppliesPetsUlta Beauty at TargetTarget OpticalGift CardsBullseye’s PlaygroundDealsClearanceTarget New Arrivals Target Finds #TargetStyleStore EventsAsian-Owned Brands at TargetBlack-Owned or Founded Brands at TargetLatino-Owned Brands at TargetWomen-Owned Brands at TargetLGBTQIA+ ShopTop DealsTarget Circle DealsWeekly AdShop Order PickupShop Same Day DeliveryRegistryRedCardTarget CircleFind Stores
Target Circle™Target Circle™ CardTarget Circle 360™Registry & Wish ListWeekly AdFind Stores
Desitin Daily Defense Baby Diaper Rash Cream with Zinc Oxide -16oz - 2 of 4Desitin Daily Defense Baby Diaper Rash Cream with Zinc Oxide -16oz - 3 of 4Desitin Daily Defense Baby Diaper Rash Cream with Zinc Oxide -16oz - 4 of 4
Desitin Daily Defense Baby Diaper Rash Cream with Zinc Oxide -16oz - 1 of 4

Desitin Daily Defense Baby Diaper Rash Cream with Zinc Oxide -16oz

$16.99

In Stock

Eligible for registries and wish lists

At a glance

About this item

Highlights

  • Desitin Daily Defense Diaper Rash Healing Cream to soothe, treat & prevent baby diaper rash
  • The fast-acting formula of this infant diaper rash cream prevents diaper rash from the first use
  • #1 choice for diaper rash relief by pediatricians & parents, it is both easy to apply and remove
  • It instantly forms a protective layer on your baby's skin for diaper rash relief and prevention
  • Made with 13% zinc oxide, it is hypoallergenic and specially formulated for babies' tender skin
  • Dermatologist- & Pediatrician-tested, it is clinically shown to provide diaper rash relief
  • Paraben-, phthalate-, fragrance and dye-free so it's gentle enough to use at every diaper change
  • This skin barrier cream helps seal out wetness to treat diaper rash from the first signs

Description

Use Desitin Daily Defense Diaper Rash Cream every day to soothe, treat and prevent baby diaper rash. This hypoallergenic and pediatrician-tested formula instantly forms a protective barrier on your baby's tender skin and is clinically shown to provide diaper rash relief. The rash healing cream is designed to work at the first hint of diaper rash to help heal and soothe your baby's skin. Made with fast-acting 13% zinc oxide skin protectant formula, this barrier cream helps seal out wetness and provides protection from the first use. It is dermatologist-tested and free of parabens, phthalates, fragrances and dyes, so it's gentle enough to use at every diaper change. The #1 choice of pediatricians and parents, the rich, creamy formula goes on smoothly and wipes off easily, making Desitin Daily Defense Baby Diaper Rash Cream your trusted partner for treating diaper rash from the first signs.
Scent: Unscented
Suggested Age: Newborn and Up
Health Facts: Dye-Free, Contains Zinc Oxide, Paraben-Free, Phthalate-Free, Hypoallergenic, No Fragrance Added, Aluminum-Free
Active Ingredient Strength Value: 13
Product Form: Cream
Active Ingredient(s): Zinc Oxide 13%
Package Quantity: 1
Net weight: 16 Ounces
Features: Pediatrician Tested, Soothing, Dermatologist Tested
TCIN: 13682250
UPC: 074300495163
Item Number (DPCI): 007-08-0733
Origin: Made in the USA or Imported
Healthcare Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers.
If the item details aren’t accurate or complete, we want to know about it.

Active ingredients

zinc oxide' '13.0%

Purpose

Skin protectant

Uses

• helps treat and prevent diaper rash • protects chafed skin due to diaper rash and helps seal out wetness

Directions

Directions • change wet and soiled diapers promptly • cleanse the diaper area • allow to dry • apply cream liberally as often as necessary, with each diaper change, especially at bedtime or anytime when exposure to wet diapers may be prolonged

Other information

Previously Desitin® Rapid Relief, © J&JCI 2018

Inactive ingredients

inactive ingredients: water, mineral oil, petrolatum, beeswax, dimethicone, sorbitan sesquioleate, microcrystalline wax, peg-30 dipolyhydroxystearate, aloe barbadensis leaf extract, glycerin, tropolone, tocopheryl acetate, 1,2-hexanediol, caprylyl glycol, magnesium sulfate, potassium hydroxide, phenoxyethanol

Shipping details

Estimated ship dimensions: 3.94 inches length x 3.58 inches width x 3.47 inches height
Estimated ship weight: 1.12 pounds

Return details

This item can be returned to any Target store or Target.com.
This item must be returned within 90 days of the date it was purchased in store, shipped, delivered by a Shipt shopper, or made ready for pickup.
See the return policy for complete information.

Q: Does the jar have a protective seal? Mine arrived without a seal or foil protecting the cream. Just a target tape over the lid so it wouldn’t spill or pop open during shipping.

submitted by Curious - 1 year ago

  • A: Thank you so much for bringing this to our attention! We appreciate your review and would like to learn more about your experience. When you have a moment, please give us a call at 1-800-720-3843. Our team is available Monday-Friday, 9:00 am-5:30 pm EST. We hope to hear from you soon!

    submitted byJohnson & Johnson - 1 year ago
    Brand expert
See all questions (1)

Additional product information and recommendations

Discover more options

Frequently bought together

More to consider

Millie Moon Luxury Disposable Diapers - (Select Size and Count)

$8.99 - $49.99
$30 GiftCard with $100 select diapers & wipes purchase
Millie Moon Luxury Disposable Diapers - (Select Size and Count)
4.5 out of 5 stars with 29580 ratings
4.7 out of 5 stars with 4421 reviews
quality: 4.5 out of 5
value: 4.53 out of 5
93% would recommend
43 recommendations
5 out of 5 stars
8 January, 2026
originally posted on desitin.com
Image

Greatfull

It's so good For baby I use everyday I need it everyday
Siama
Did you find this review helpful?
4 out of 5 stars
4 January, 2026
originally posted on desitin.com
Image

Requesting 4.8oz to be back in-stock

Desitin all 3 products are great and help with my baby to prevent diaper rash. Realized y'all bring back 16oz tub which is great for home use, but it will be great y'all bring back 4.8oz. Appreciated!!
Did you find this review helpful?
5 out of 5 stars
2 January, 2026
originally posted on influenster.com
Image

Super

This cream is the best, the results are great in a very short time, it acts, the consistency is good, it is creamy and the packaging is very good, it is not big, which is great for your bag
johuc1_773
Did you find this review helpful?
5 out of 5 stars
30 December, 2025
originally posted on influenster.com
Image

Excellent product.

I love this cream; it's the best I've used since my baby was born, and since the first time I tried it, I haven't used anything else. It's not sticky or too greasy, and it perfectly protects my baby's skin. Since I started using it, she has never had diaper rash.
yailina7_2838
Did you find this review helpful?
5 out of 5 stars
28 December, 2025
originally posted on influenster.com
Image

Recommended

This cream is a product that I use daily with my baby, it helps him not to have pinkish or burns, since day 1 and thank God he has never suffered from burns, it has an excellent consistency, a super mild smell and he has not had allergies.
mariab1742_2933
Did you find this review helpful?
5 out of 5 stars
15 December, 2025
originally posted on influenster.com
Image

A must-have in our diaper bag

I’ve been using Desitin Daily Defense for my twins and it really works. It helped clear up diaper rash quickly and also prevents new irritation when used daily. The texture is smooth and easy to apply, not overly thick, and it doesn’t have a strong smell.
alinar87_6667
Did you find this review helpful?
5 out of 5 stars
10 December, 2025
originally posted on influenster.com
Image

Great quality

Really like the ease of use, texture and value of this balm for starters. It is easy to apply, smells great, smooths and condition. It is non sticky has a good hold. It’s always comes in handy
kamoyan1_2079
Did you find this review helpful?
5 out of 5 stars
25 November, 2025
originally posted on influenster.com
Image

Good!

I’ve been using Desitin cream for my baby, and I’m really impressed. It works quickly to soothe any skin irritation and creates a long-lasting protective barrier — the durability of the effect is amazing. I also appreciate the ingredients, which are gentle and safe for sensitive skin. Highly recommend for everyday use! It easily helps to eliminate redness, has a pleasant texture, is easy to apply to the skin. Convenient and roomy packaging lasts a long time. I take it with me everywhere.
alinaars_4571
Did you find this review helpful?
5 out of 5 stars
24 November, 2025
originally posted on influenster.com
Image

Fast Relief & Gentle on Baby's Skin

This cream has become a must-have in our routine. The texture is smooth and easy to apply, and the consistency spreads evenly without being too thick. I love the compact 2 oz packaging because it’s perfect for the diaper bag and stores well without leaking or drying out. For maintenance, it stays in great condition even with daily use. My baby doesn’t get diaper rash often, but whenever she does and I put this on right away, the relief is almost instant. It’s gentle, effective, and very reliable.
ladylynt_6074
Did you find this review helpful?
5 out of 5 stars
17 November, 2025
originally posted on influenster.com
Image

Our daily diaper cream - keeps rash away and a lit

We use this DAILY as the name of the product reads! It is our go to diaper cream for our twins and we must have gone through 50 tubs by now. The tub last a very long time as you don’t need a ton - it spreads so easily and really keeps rashes away! Easy to wipe off or wash off in the tub. My parents used Desitin with me and now I’m using it for my babies! It’s a classic for a reason.
sarahg796_8727
Did you find this review helpful?
5 out of 5 stars
17 November, 2025
originally posted on influenster.com
Image

The best

Fragrance is ok. Coverage is perfect. Residue is ok. Skin/Bottom feels better after a few days. Packaging is nice. Its worth the price is think.
verazo_4389
Did you find this review helpful?
5 out of 5 stars
28 October, 2025
originally posted on influenster.com
Image

I love it because it protects my baby

Desitin Daily Defense is your daily ally to protect your baby's delicate skin and treat diaper rash from the first signs. With a fast-acting and proven formula, this cream instantly creates a protective barrier to relieve discomfort and seal moisture. Recommended by pediatricians and parents, it is ideal to use with each diaper change as a preventive and relief measure.
kimberlyt381_8883
Did you find this review helpful?
5 out of 5 stars
24 October, 2025
originally posted on influenster.com
Image

For the daily use of the baby

The desitin daily defense cream has a very good effectiveness, protects babies from diaper rash with soft and hypoallergenic ingredients its packaging is suitable to wear and has a simple smell, it has a price affordable to your pockets
willbaniaf1_4224
Did you find this review helpful?
5 out of 5 stars
24 October, 2025
originally posted on influenster.com
Image

Good use daily for baby skin

Really helpful. I’m preventing rashes on my baby, good packaging for on the go and good pricing all around has no sent and is baby safe. Very effective.
aluminuss_4577
Did you find this review helpful?
2 out of 5 stars
23 October, 2025
originally posted on influenster.com
Image

Not a fan

I didn’t care for Desitin. It never healed the diaper rash on my daughter. It also seemed to burn when I applied it because she would scream and scream.
suzyrudd_7719
Did you find this review helpful?
5 out of 5 stars
23 October, 2025
originally posted on influenster.com
Image

Amazing

This product is very good. I use it daily with my baby when changing the diaper and it has never suffered from any irritation, I find it very effective and this packaging is very versatile to carry in the bag when we go out. Love it
glodebeauty_7899
Did you find this review helpful?
5 out of 5 stars
22 October, 2025
originally posted on influenster.com
Image

Great one

Best diaper cream with great scent. It has great effective too and comes with great packaging. Value for money is reasonable, ingredients used in this product is great too.
axam1_1957
Did you find this review helpful?
5 out of 5 stars
17 October, 2025
originally posted on influenster.com
Image

Great for babies & adulte

I love these products! My kids used to get a lot of diaper rash, and now that my youngest is potty training, I still use this cream to help heal and soothe any irritation. It works fast—rashes clear up in just a few days! I absolutely love Desitin and would recommend it to any parent.
starkovanewlin_7464
Did you find this review helpful?
5 out of 5 stars
4 October, 2025
originally posted on influenster.com
Image

Perfect for diaper rash

This is so great!! Takes away diaper rash overnight and is very affordable. They have a regular and and extra strength. I won’t use anything else for my baby.
brianag109_2242
Did you find this review helpful?
5 out of 5 stars
3 October, 2025
originally posted on influenster.com
Image

A reliable cream that soothes diaper rash quickly

Desitin Daily Defense Cream works amazingly well to prevent and treat diaper rash. The texture is thick yet spreads easily and creates a protective barrier that lasts for hours. It starts soothing redness almost immediately, and within a day or two the irritation is gone. The ingredients feel safe and gentle on delicate skin, and I appreciate that it’s fragrance-free. The packaging is convenient and the tube makes it easy to dispense without mess. For the price, it’s excellent value because a little goes a long way.
lizas53_8338
Did you find this review helpful?

Get top deals, latest trends, and more.

Privacy policy

Footer

About Us

About TargetCareersNews & BlogTarget BrandsBullseye ShopSustainability & GovernancePress CenterAdvertise with UsInvestorsAffiliates & PartnersSuppliersTargetPlus

Help

Target HelpReturnsTrack OrdersRecallsContact UsFeedbackAccessibilitySecurity & FraudTeam Member ServicesLegal & Privacy

Stores

Find a StoreClinicPharmacyTarget OpticalMore In-Store Services

Services

Target Circle™Target Circle™ CardTarget Circle 360™Target AppRegistrySame Day DeliveryOrder PickupDrive UpFree 2-Day ShippingShipping & DeliveryMore Services
PinterestFacebookInstagramXYoutubeTiktokTermsCA Supply ChainPrivacy PolicyCA Privacy RightsYour Privacy ChoicesInterest Based AdsHealth Privacy Policy