Solid-Phase Organic Syntheses, Volume 2 - Wiley Solid-Phase Organic Syntheses by Peter J H Scott Hardcover

About the Book

"This series informs researchers of major accomplishments in solid-phase organic synthesis and provides actual experimental details and specific references. With this series, a reader will be able to sharpen hands-on skills by following the experimental procedures and refining understanding of the science by studying the chosen reactions. More importantly, this series guides readers in designing novel compound libraries, and may also inspire future breakthroughs. This second volume focuses on palladium chemistry in solid-phase synthesis, and discusses: palladium catalysts and reactions, procedures for preparation and utilization, ligands, and linker reactions"--

From the Back Cover

Integrates solid-phase organic synthesis with palladium chemistry

The Wiley Series on Solid-Phase Organic Syntheses keeps researchers current with major accomplishments in solid-phase organic synthesis, providing full experimental details. Following the validated, tested, and proven experimental procedures, readers can easily perform a broad range of complex syntheses needed for their own experiments and industrial applications. The series is conveniently organized into themed volumes according to the specific type of synthesis.

This second volume in the series focuses on palladium chemistry in solid-phase synthesis, exploring palladium catalysts and reactions, procedures for preparation and utilization, ligands, and linker reactions. The first part of the volume offers a comprehensive overview of the field. Next, the chapters are organized into three parts:

• Part Two: Palladium-Mediated Solid-Phase Organic Syntheses
• Part Three: Immobilized Catalysts and Ligands
• Part Four: Palladium-Mediated Multifunctional Cleavage

Each chapter is written by one or more leading international experts in palladium chemistry. Their contributions reflect a thorough examination and review of the current literature as well as their own first-hand laboratory experience. References at the end of each chapter serve as a gateway to the field's literature.

The introduction of palladium-mediated, cross-coupling reactions more than thirty years ago revolutionized the science of carbon-carbon bond formation. It has now become a cornerstone of today's synthetic organic chemistry laboratory. With this volume, researchers in organic and medicinal chemistry have access to a single resource that explains the fundamentals of palladium chemistry in solid-phase synthesis and sets forth clear, step-by-step instructions for conducting their own syntheses.

Review Quotes

"Overall, though, the adoption of an Organic Synthesesstyle is an excellent idea and works very well. Along with other related volumes, this collection serves to demystify polymer-supported methods for palladium-catalysed reactions and provides a very useful collection of clear methods. It will certainly be of interest and use to those new to the fi eld." (Platinum Metals Review, 1 July 2013)

About the Author

PETER J. H. SCOTT is an Assistant Professor in the Department of Radiology at the University of Michigan Medical School. Dr. Scott edited Linker Strategies in Solid-Phase Organic Synthesis (also from Wiley) and is the Series Editor for both the Wiley Series on Radiochemical Syntheses and the Wiley Series on Solid-Phase Organic Syntheses.