Applications of Toxicogenomics in Safety Evaluation and Risk Assessment - by Darrell R Boverhof & B Bhaskar Gollapudi (Hardcover)

Book Synopsis

This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process - including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.

From the Back Cover

Risk assessment and toxicogenomics -- a practical review

The past decade has seen growing interest in the use of toxicogenomics for hazard evaluation and chemical safety assessment. This book addresses the need in the field for a comprehensive, up-to-date review of this emerging technology, providing toxicologists and regulatory scientists with practical considerations to take advantage of toxicogenomics when conducting risk assessment of industrial chemicals, pharmaceuticals, agrochemicals, and consumer products.

Written by leading scientists experienced in the application of toxicogenomics data, this book includes a complete introduction to toxicogenomics and the principles of risk assessment, examines the potential of the technology to improve risk assessment practices, and offers insight into promising future trends. The emphasis throughout is on practical risk assessment, highlighting applications of toxicogenomics in the risk assessment process across diverse and important areas.

Topics include:

• Applications in mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology

• The use of toxicogenomics for enhancing mode-of-action and weight-of-evidence approaches

• The role of toxicogenomics in dose-response analysis, cross-species extrapolations, and animal alternatives

• The regulatory aspects of toxicogenomics, including chemical classification and prioritization for toxicity testing

• Strategic approaches for the integration of toxicogenomics in safetyevaluation studies

About the Author

DARRELL R. BOVERHOF, PhD, is a Senior Toxicology Specialist at The Dow Chemical Company where he leads research programs on respiratory allergy and sensitization, nanotoxicology, and toxicogenomics. Dr. Boverhof has authored or coauthored numerous peer-reviewed publications, review articles, and book chapters in the area of toxicogenomics and serves on the editorial board of the journal Toxicological Sciences.

B. BHASKAR GOLLAPUDI, PhD, is the Scientific Director of Mammalian Toxicology at The Dow Chemical Company's Global Toxicology & Environmental Research Laboratory. Dr. Gollapudi has authored or co-authored more than 80 scientific publications. He is an Associate Editor of the journal Toxicological Sciences and is currently serving as an adjunct Associate Professor of Toxicology in the Department of Public Health at the University of Michigan.